Article

A First-in-human phase I study of an innovative selective inhibitor targeting coagulation factor XI/XIa in healthy volunteers

2024-08-26

Abstract excerpt

<h4>Aim: </h4> Coagulation factor XI (FXI) plays a crucial role in the intrinsic coagulation pathway, and inhibitors targeting it may mitigate the risk of hemorrhage compared to anticoagulants currently on the market. SKB336, a novel selective inhibitor of FXI/FXIa, has been shown to prolong the activated partial thromboplastin time (APTT) in in-vitro and in-vivo studies. This study aimed to determine the safety,...

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Literature Corpus work: fc4cdfef-6722-5386-a981-2b851a62b91e
DOI: 10.22541/au.172471236.69356436/v1

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