Article

Integrative blood transcriptomics identifies U1-snRNP gene repression and miRNA–mRNA regulatory hubs in pre-clinical Parkinson’s Disease

2026-04-01

Abstract excerpt

<title>Abstract</title> <p>Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterised by the loss of dopaminergic neurons and the accumulation of intraneuronal misfolded α-synuclein aggregates. Despite advances in understanding the underlying molecular mechanisms of PD, diagnosis still relies largely on clinical symptoms that appear relatively late in disease progression. To advance both t...

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Literature Corpus work: fc16af67-310d-535b-9b61-bb2c5c79663c
DOI: 10.21203/rs.3.rs-9074426/v1

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