Article

mRNA vaccine induces cytotoxic CD8+ T-cell cross-reactivity against SARS-CoV-2 Omicron variant and regulates COVID-19 severity

2022-04-11

Abstract excerpt

<title>Abstract</title> Understanding the T-cell responses involved in inhibiting COVID-19 severity is crucial for developing new therapeutic and vaccine strategies. Here, we characterized SARS-CoV-2 spike-specific CD8+ T cells interacting with overlapping peptides on peripheral blood mononuclear cells from acute-phase COVID-19 patients. Relative to severe COVID-19, patients with mild COVID-19 had more frequen...

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Literature Corpus work: fbedf4f7-ac67-540c-9456-b7881bf3c655
DOI: 10.21203/rs.3.rs-1364513/v1

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