Article

Vaccines Elicit Highly Cross-Reactive Cellular Immunity to the SARS-CoV-2 Omicron Variant

2022-01-03

Abstract excerpt

The highly mutated SARS-CoV-2 Omicron (B.1.1.529) variant has been shown to evade a substantial fraction of neutralizing antibody responses elicited by current vaccines that encode the WA1/2020 Spike immunogen 1 , resulting in increased breakthrough infections and reduced vaccine efficacy. Cellular immune responses, particularly CD8+ T cell responses, are likely critical for protection against severe SARS-CoV-2 di...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b5910f48-3c1c-5f8d-9d76-b5a58d8f7876
DOI: 10.1101/2022.01.02.22268634

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Vaccines Elicit Highly Cross-Reactive Cellular Immunity to the SARS-CoV-2 Omicron VariantDOI 10.1101/2022.01.02.22268634Read

Vaccines elicit highly conserved cellular immunity to SARS-CoV-2 OmicronSemantic proximity Read

Humoral and Cellular Immune Responses of COVID-19 vaccines against SARS-Cov-2 Omicron variant: a systemic reviewSemantic proximity Read

Vaccine-induced spike- and nucleocapsid-specific cellular responses maintain potent cross-reactivity to SARS-CoV-2 Delta and Omicron variantsSemantic proximity Read

<strong>Efficacy of COVID-19 Vaccines Against the Omicron Variant of SARS-CoV-2</strong>Semantic proximity Read

Limited Cross-Variant Immunity after Infection with the SARS-CoV-2 Omicron Variant Without VaccinationSemantic proximity Read

Divergent SARS CoV-2 Omicron-specific T- and B-cell responses in COVID-19 vaccine recipientsSemantic proximity Read

Delta infection following vaccination elicits potent neutralizing immunity against the SARS-CoV-2 OmicronSemantic proximity Read

Post-vaccination T cell immunity to omicronSemantic proximity Read

SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to OmicronSemantic proximity Read

Assessment of T-cell Reactivity to the SARS-CoV-2 Omicron Variant by Immunized IndividualsSemantic proximity Read

SARS-CoV-2 T Cell Responses Elicited by COVID-19 Vaccines or Infection Are Expected to Remain Robust against Omicron.Semantic proximity Read

The BTN162b2 Vaccine Induces Humoral and Cellular Immune Memory to Wuhan Strain SARS-CoV-2 and the Omicron Variant in Children 5 to 11 Years of AgeSemantic proximity Read