Article

Cystin gene mutations cause autosomal recessive polycystic kidney disease associated with altered <i>Myc</i> expression

2020-02-19

Abstract excerpt

Mutation of the Cys1 gene underlies the renal cystic disease in the Cys1 cpk / cpk ( cpk) mouse that phenocopies human autosomal recessive polycystic kidney disease (ARPKD). Cystin, the protein product of Cys1 , is expressed in the primary apical cilia of renal ductal epithelial cells. In previous studies, we showed that cystin regulates Myc expression via interaction with the tumor suppressor, necdin. Here,...

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Literature Corpus work: fbdfb2c5-2a43-5060-ad0a-61a21c155e28
DOI: 10.1101/2020.02.18.946285

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