Article

Prevalence of tumor genomic alternations in homologous recombination genes among Taiwanese breast cancers

2021-04-14

Abstract excerpt

<title>Abstract</title> <p>Purpose Deleterious BRCA1 / 2 mutations are among the most highly pathogenic variants in hereditary breast and ovarian cancer syndrome. PARP (poly ADP ribose polymerase) inhibitors selectively cause failure of single-strand but does not affect double-strand DNA break repair, and ant-tumor activity is observed in BRCA mutant breast cancers. Recently genes implicated into the homologous r...

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Literature Corpus work: fb743103-9ea3-53c0-807e-ee6d1165f8e2
DOI: 10.21203/rs.3.rs-366269/v1

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