Article

Preoperative Cholinergic Signatures Drive Segregated Brain Architecture in Postoperative Delirium

2025-11-23

Abstract excerpt

<title>Abstract</title> <p>Delirium affects up to 50% of hospitalised, older patients and is linked to increased risk of death and long-term cognitive decline. Age-related changes in the ascending arousal system (AAS), including cholinergic and noradrenergic nuclei, may contribute to delirium vulnerability. Static and dynamic functional connectivity, across cortical and subcortical regions, was extracted from pre...

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Literature Corpus work: fb1efeef-425f-5ffa-9fec-748b2693cc1d
DOI: 10.21203/rs.3.rs-7881643/v1

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