A Novel Genome Optimization Tool for Chromosome-Level Assembly across Diverse Sequencing Techniques

Abstract excerpt

This paper introduces a novel genome assembly optimization tool named LOCLA, which stands for “Local Optimization for Chromosome-Level Assembly”. It identifies reads and contigs aligned locally with high quality on gap flanks or scaffold boundaries of draft assemblies for gap filling and scaffold connection. LOCLA applies to both de novo and reference-based assemblies. It can also utilize reads produced by diverse...

Topics

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• Chromosome Mapping
• Chromosomes, Human
• Diploidy
• Genome, Human
• Genomics
• Haplotypes
• High-Throughput Nucleotide Sequencing
• Reference Standards

Identifiers and source

Literature Corpus work

fa31018d-41b6-5d8b-87d3-47e835934c00

DOI

10.1101/2023.07.20.549842