Article

Syndecan 2 regulates hematopoietic lineages and infection resolution in zebrafish

2020-05-05

Abstract excerpt

Syndecan 2 ( Sdc2 ) is a transmembrane cell-surface heparan sulfate proteoglycan (HSPG) that has been implicated in the regulation of cell-cell signaling pathways and cell-matrix interactions. Surprisingly, homozygous recessive maternal zygotic (MZ) sdc2 null mutants in zebrafish appear to have normal development, normal morphology and are viable and fertile in adulthood. Whole transcriptome RNA sequencing, FACS...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fa2a018e-018c-5ec3-be20-70df1224cd91
DOI: 10.1101/2020.05.04.076786

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Syndecan 2 regulates hematopoietic lineages and infection resolution in zebrafishDOI 10.1101/2020.05.04.076786Read

Knockdown of hspg2 is associated with abnormal mandibular joint formation and neural crest cell dysfunction in zebrafishSemantic proximity Read

Use of the zebrafish system to study primitive and definitive hematopoiesis.Semantic proximity Read

Modeling hematopoietic disorders in zebrafishSemantic proximity Read

Zebrafish as a model of human hematologic disorders.Semantic proximity Read

Isthmin 1 (ism1) is required for normal hematopoiesis in developing zebrafishSemantic proximity Read

Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects.Semantic proximity Read

<i>rapunzel5</i> is necessary for normal hematopoietic development in zebrafishSemantic proximity Read

Zebrafish as a model for normal and malignant hematopoiesisSemantic proximity Read

The endothelial scavenger receptor <i>stab2</i> is required for proper hematopoietic stem and progenitor cell development in the fetal blood stem cell nicheSemantic proximity Read

Hematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic hemogenic endotheliumSemantic proximity Read

Syndecan receptors: pericellular regulators in development and inflammatory diseaseSemantic proximity Read

GATA2 haploinsufficiency causes an epigenetic feedback mechanism resulting in myeloid and erythroid dysplasiSemantic proximity Read