Article

PRECISE: A domain adaptation approach to transfer predictors of drug response from pre-clinical models to tumors

2019-02-15

Abstract excerpt

<h4>Motivation</h4> Cell lines and patient-derived xenografts (PDX) have been used extensively to understand the molecular underpinnings of cancer. While core biological processes are typically conserved, these models also show important differences compared to human tumors, hampering the translation of findings from pre-clinical models to the human setting. In particular, employing drug response predictors gener...

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Literature Corpus work: f9bfab00-7b8d-5a5e-9987-99ff371f6246
DOI: 10.1101/536797

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