Article

Computer modelling of metabolic adaptions during mitochondrial dysfunction and machine learning to predict novel mitochondrial disease genes

2019-01-01

Abstract excerpt

Mitochondria are organelles found in almost every eukaryote and are primarily responsible for generating chemical energy in the form of adenosine triphosphate. This thesis investigates two main causes of mitochondrial dysfunction: mitochondrial toxicity arising from side-effects of drugs; and mitochondrial diseases arising from defects in nuclear-encoded genes. Novel chemical entities being developed as drug leads...

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Literature Corpus work: f9a201b0-f0bd-51ab-8145-40701bc7abb5
DOI: 10.17863/cam.54007

Open publication

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