Article

Functional characterisation of the human mitochondrial ATP-Mg/Pi carriers and their disease-causing variants

2019-01-01

Abstract excerpt

The mitochondrial ATP-Mg/Pi carriers (APCs) catalyses the exchange of adenine nucleotides for phosphate across the mitochondrial inner membrane, which is regulated by calcium. They are responsible for modulating the adenine nucleotide pool in the mitochondrial matrix, and therefore have a pivotal role in meeting the energetic demands of the cell. They consist of three domains; an EF hand-containing regulatory doma...

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Literature Corpus work: f99a3c06-cd46-5b22-89e6-15c5fe5cf565
DOI: 10.17863/cam.63923

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