Article

Estimating chromosome sizes from karyotype images enables validation of <i>de novo</i> assemblies

2022-05-24

Abstract excerpt

Highly contiguous genome assemblies are essential for genomic research. Chromosome-scale assembly is feasible with the modern sequencing techniques in principle, but in practice, scaffolding errors frequently occur, leading to incorrect number and sizes of chromosomes. Relating the observed chromosome sizes from karyotype images to the generated assembly scaffolds offers a method for detecting these errors. Here,...

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Literature Corpus work: f9416609-4306-5ae4-bc34-4d9fd2da7c32
DOI: 10.1101/2022.05.22.492982

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