Article

KRT17 stabilizes EPN1 via inhibiting SMURF1-mediated ubiquitination to modulate Wnt/β-catenin signaling output and stem-like traits in ovarian cancer

2026-02-25

Abstract excerpt

<h4>Background</h4> Ovarian cancer (OC) progression and chemoresistance are closely linked to dysregulated oncogenic signaling, including Wnt/β-catenin pathways that contribute to cancer stem-like traits. However, the upstream mechanisms connecting cytoskeletal regulation to Wn/β-catenin signaling in OC remain incompletely understood. Keratin 17 (KRT17), a type I intermediate filament protein, has been implicated...

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Literature Corpus work: f9178192-ddbe-5850-84e9-75e394e8f155
DOI: 10.64898/2026.02.20.707140

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