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A <i>Mycobacterium tuberculosis</i> secreted virulence factor disrupts host snRNP biogenesis

2024-02-06

Abstract excerpt

We earlier reported that Mycobacterium tuberculosis ( Mtb ) alters host RNA splicing to help its intracellular growth. Here, we report an unprecedented mechanism whereby a secreted virulence factor from Mtb interferes with the biogenesis of key spliceosomal components, causing an altered RNA splicing pattern. A high-throughput yeast-2-hybrid screen identified several Mtb -secreted proteins that can interact wi...

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Literature Corpus work
f900f64e-e1db-5215-b0ff-a6d460e7fc64
DOI
10.1101/2024.02.06.579120
Open publication

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A <i>Mycobacterium tuberculosis</i> secreted virulence factor disrupts host snRNP biogenesisDOI 10.1101/2024.02.06.579120
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