Article

ROKET: Associating Somatic Mutation with Clinical Outcomes through Kernel Regression and Optimal Transport

2021-12-24

Abstract excerpt

Somatic mutations in cancer patients are inherently sparse and potentially high dimensional. Cancer patients may share the same set of deregulated biological processes perturbed by different sets of somatically mutated genes. Therefore, when assessing the associations between somatic mutations and clinical outcomes, gene-by-gene analyses is often under-powered because it does not capture the complex disease mechan...

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Literature Corpus work: f8922c33-c276-5008-a1f2-66512067eb03
DOI: 10.1101/2021.12.23.474064

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