Article

Pulmonary epithelial barrier and immunological functions at birth and in early life - key determinants of the development of asthma? A description of the protocol for the Breathing Together study

2018-05-17

Abstract excerpt

<h4>Background: </h4> Childhood asthma is a common complex condition whose aetiology is thought to involve gene-environment interactions in early life occurring at the airway epithelium, associated with immune dysmaturation. It is not clear if abnormal airway epithelium cell (AEC) and cellular immune system functions associated with asthma are primary or secondary. To explore this, we will (i) recruit a birth...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f869d9b9-f9b0-5faa-9457-82e9da8196fe
DOI: 10.12688/wellcomeopenres.14489.1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pulmonary epithelial barrier and immunological functions at birth and in early life - key determinants of the development of asthma? A description of the protocol for the Breathing Together studyDOI 10.12688/wellcomeopenres.14489.1Read

Airway Epithelium Respiratory Illnesses and Allergy (AERIAL) birth cohort: study protocolSemantic proximity Read

Immune mechanisms and development of childhood asthma.Semantic proximity Read

Childhood asthma: pathogenesis and phenotypes.Semantic proximity Read

What Have Mechanistic Studies Taught Us About Childhood Asthma?Semantic proximity Read

Maturation of the gut microbiome and risk of asthma in childhoodSemantic proximity Read

The early origins of asthma: who is really at risk?Semantic proximity Read

Characterizing wheeze phenotypes to identify endotypes of childhood asthma, and the implications for future management.Semantic proximity Read

Role of innate immunity in the development of allergy and asthma.Semantic proximity Read

Understanding respiratory microbiome–immune system interactions in health and diseaseSemantic proximity Read

Single-cell profiling demonstrates the combined effect of wheeze phenotype and infant viral infection on airway epithelial development.Semantic proximity Read

Paired Airway and Blood Multiomics Defines Coordinated Immune Adaptation Across the Airway–Blood Axis in Preterm InfantsSemantic proximity Read

Early life inter-kingdom interactions shape the immunological environment of the airwaysSemantic proximity Read