Article

Fibroblast-to-Myofibroblast Differentiation in Gut Wall and Abdominal Soft Tissue Corrupts Normal Bowel Function in “Irritable Bowel Syndrome”: A Hypothesis

2025-11-03

Abstract excerpt

Irritable Bowel Syndrome (IBS) is a common gastrointestinal disorder characterized by chronic abdominal discomfort, pain, and altered bowel habits, as well as extraintestinal manifestations such as fatigue, musculoskeletal pain, gastroesophageal reflux, depression, and anxiety. Despite prevalences of approximately 10% in the general population, its fundamental etiopathogenesis remains unclear. Current theories mai...

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Literature Corpus work: f84fc58c-8db7-564e-8061-8fb7f5c43741
DOI: 10.20944/preprints202511.0024.v1

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