Article
IBS and IBD - separate entities or on a spectrum?
Nature reviews. Gastroenterology & hepatology - 26 Sept 2016
Spiller Robin, Major Giles
Abstract excerpt
The acute phase of IBD with inflamed gut and often ulcerated mucosa is clearly different from the apparently normal mucosa characteristic of IBS. However, more detailed assessment has detected immune activation, increased gut permeability, increased mucosal serotonin availability, abnormalities of enteric nerve structure and function, and dysbiosis in gut microbiota in IBS - all features seen in IBD. Furthermore,...
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