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Article

What Causes Functional Gastrointestinal Disorders? A Proposed Disease Model.

The American journal of gastroenterology - 1 Jan 2020

Talley Nicholas J

Abstract excerpt

Chronic unexplained gastrointestinal symptoms impact more than 1 in 5 Americans and their families; these disorders include the irritable bowel syndrome (IBS) and functional dyspepsia (FD), currently classified by Rome IV as functional gastrointestinal disorders. By definition, IBS and FD have no established pathology, but emerging evidence suggests this paradigm may need revision. Immune activation and, in...

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PMID: 31895721
DOI: 10.14309/ajg.0000000000000485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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