Article

Fibroblasts-derived extracellular vesicles contain SFRP1 and mediate pulmonary fibrosis

2022-12-23

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a lethal and chronic lung disease characterized by aberrant intercellular communication, increased extracellular matrix (ECM) deposition, and destruction of functional lung tissue. Extracellular vesicles (EVs) accumulate within the lung in IPF, but their cargo and biological effects remain unclear. Here, we provide the entire the proteome of EV and non-EV fraction during pulm...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f84aced4-852b-5ada-aeda-f359c7ceb761
DOI: 10.1101/2022.12.22.521499

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Fibroblasts-derived extracellular vesicles contain SFRP1 and mediate pulmonary fibrosisDOI 10.1101/2022.12.22.521499Read

Proteomic Analysis Reveals Key Proteins in Extracellular Vesicles Cargo Associated with Idiopathic Pulmonary Fibrosis In VitroSemantic proximity Read

SFTPB in serum extracellular vesicles as a biomarker of progressive pulmonary fibrosisSemantic proximity Read

Mechanisms and Therapeutic Potential of Myofibroblast Transformation in Pulmonary FibrosisSemantic proximity Read

Stem-cell extracellular vesicles and lung repairSemantic proximity Read

A novel protein signature from plasma extracellular vesicles for non-invasive differential diagnosis of idiopathic pulmonary fibrosisSemantic proximity Read

Extracellular Vesicles’ Role in the Pathophysiology and as Biomarkers in Cystic Fibrosis and COPDSemantic proximity Read

Urine-derived exosomes from individuals with IPF carry pro-fibrotic cargoSemantic proximity Read

Extracellular Vesicles as Central Mediators of COPD PathophysiologySemantic proximity Read

Extracellular vesicle-mediated cellular crosstalk in lung repair, remodelling and regenerationSemantic proximity Read

Lung derived extracellular vesicles have distinct pro-repair effects, depending on the age of their source tissueSemantic proximity Read

Single-Cell RNA Sequencing Reveals Monocyte-Derived Interstitial Macrophages with a Pro-Fibrotic Phenotype in Bleomycin-Induced Pulmonary Fibrosis.Semantic proximity Read

Modeling cell-cell interactions to advance drug discovery in Idiopathic Pulmonary FibrosisSemantic proximity Read