Article

Conflicts with diarrheal pathogens trigger rapid evolution of an intestinal signaling axis

2020-03-30

Abstract excerpt

The pathogenesis of infectious diarrheal diseases is largely attributed to enterotoxin proteins that disrupt intestinal water absorption, causing severe dehydration. Despite profound health consequences, the impacts of diarrhea-causing microbes on the evolutionary history of host species are largely unknown. We investigated patterns of genetic variation in mammalian Guanylate Cyclase-C (GC-C), an intestinal recept...

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Literature Corpus work: f83d3fcf-d326-59cb-977d-a981cd163c5e
DOI: 10.1101/2020.03.29.014761

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