Epigenetic alterations of the promoter region of the POMC gene in adolescent depressive disorder patients with non-suicidal self-injury behaviors

Abstract excerpt

<h4>Background: </h4> The incidence of non-suicidal self-injury (NSSI) behavior among adolescents increases year by year. Patients with a history of both depression and NSSI behaviors tend to have greater risk of suicide. At present, the mechanism of adolescent depressive disorder patients with NSSI behaviors is not clear, epigenetic mechanism may be involved. Proopiomelanocortin ( POMC ) gene may be associated wi...

Topics

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• Adverse Childhood Experiences
• Depression
• East Asian People
• Gene-Environment Interaction
• Hypothalamo-Hypophyseal System
• Pituitary-Adrenal System
• Self-Injurious Behavior
• Tacrolimus Binding Proteins

Identifiers and source

Literature Corpus work

f7c066d3-4a02-5d9f-a48b-330a876e4e7f

DOI

10.21203/rs.3.rs-37091/v1