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Article

Adverse childhood experiences, depressive symptoms, and non-suicidal self-injury in Chinese adolescents: the moderating role of SKA2 gene rs7208505 polymorphism.

Behavioral and brain functions : BBF - 20 Apr 2026

Wang Yihan, Liang Qingqing, Zhou Wei, Wang Yingxue, Tian Susu, Hu Xinyi, Tian Jiayi, Liu Yuxuan, Fang Haiyan, Wang Wei

Abstract excerpt

BACKGROUND: The Hypothalamic-pituitary-adrenal axis (HPA) and its single nucleotide polymorphisms (SNPs) potentially influence depressive symptoms and non-suicidal self-injury (NSSI) among adolescents. Adverse childhood experiences (ACEs) may dysregulate HPA axis functioning, with these complex gene-environment interactions showing significant heterogeneity across individuals. This study examined whether...

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Source

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Identifiers

PMID: 42010618
DOI: 10.1186/s12993-026-00332-2
PMCID: PMC13289380

Genes

SKA2
AVPR1B
FKBP5
SLC1A3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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