Article

Steroidome Dysregulation and Complement C4 Copy Number Variation in Men with Central Serous Chorioretinopathy

2025-10-21

Abstract excerpt

<h4>Background</h4> Central serous chorioretinopathy (CSCR) predominantly affects middle-aged men, in which systemic glucocorticoid exposure is a well-established risk factor. Genetic studies have implicated copy number variation (CNV) in complement component 4 (C4), located within the RCCX module alongside the steroid 21-hydroxylase gene (CYP21A2), in modifying disease susceptibility. However, the relationship b...

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Literature Corpus work: f68db226-ec6b-5789-b281-6491d35e70b0
DOI: 10.1101/2025.10.19.25338305

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