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A Homozygous CNP Missense Mutation in Weimaraners With an Adult-Onset Neurodegenerative Disease, Myelin Abnormalities and Accumulation of Lipofuscin-Like Inclusions

2024-01-30

Abstract excerpt

Abstract: A progressive neurological disorder was observed in a male neutered Weimaraner. Clinical signs included fecal incontinence, lethargy, moderate paraparesis, proprioceptive pelvic limb ataxia, falling, cognitive decline, incoordination, decreased interest in food, changes in posture, and episodes of trance-like behavior. Neurologic signs were first observed at approximately 4 years, 10 months of age and pr...

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Literature Corpus work: f67f8869-6944-55f9-a489-8b79303a44ff
DOI: 10.20944/preprints202401.1986.v1

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