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Article

Homozygous CNP Mutation and Neurodegeneration in Weimaraners: Myelin Abnormalities and Accumulation of Lipofuscin-like Inclusions.

Genes - 15 Feb 2024

Keller Stefan H, Johnson Gary S, Bullock Garrett, Mhlanga-Mutangadura Tendai, Schwartz Malte, Pattridge Savannah G, Guo Juyuan, Kortz Gregg D, Katz Martin L

Abstract excerpt

A progressive neurological disorder was observed in a male neutered Weimaraner. Clinical signs included fecal incontinence, lethargy, moderate paraparesis, proprioceptive pelvic limb ataxia, falling, cognitive decline, incoordination, decreased interest in food, changes in posture, and episodes of trance-like behavior. Neurologic signs were first observed at approximately 4 years, 10 months of age and progressed...

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Identifiers

PMID: 38397235
DOI: 10.3390/genes15020246
PMCID: PMC10888007

Genes

CNP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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