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Article

Lysosomal storage disease associated with a CNP sequence variant in Dalmatian dogs.

Gene - 1 Jul 2022

Bullock Garrett, Johnson Gary S, Mhlanga-Mutangadura Tendai, Petesch Scott C, Thompson Samantha, Goebbels Sandra, Katz Martin L

Abstract excerpt

A progressive neurological disorder was identified in purebred Dalmatian dogs. The disease is characterized by anxiety, pacing and circling, hypersensitivity, cognitive decline, sleep disturbance, loss of coordination, loss of control over urination and defecation, and visual impairment. Neurological signs first became apparent when the dogs were approximately 18 months of age and progressed slowly. Two affected...

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PMID: 35447247
DOI: 10.1016/j.gene.2022.146513

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