Article

Nicotinamide (aka Niacinamide) Mitigates SASP-Related Inflammation Induced by Environmental Stressors in Human Epidermal Keratinocytes

2020-03-12

Abstract excerpt

Daily exposure of skin to environmental stressors leads to molecular and morphological changes ascribed as premature aging. These stressors include solar radiation, industrial pollution, fossil fuel and carbon emissions, which cause cellular damage that induces an inflammatory response in skin. Several inflammatory components are known to be involved in triggering the senescence-associated secretory phenotype (SAS...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f585ca32-0441-5ecf-8273-4c46591dd715
DOI: 10.20944/preprints202003.0192.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nicotinamide (aka Niacinamide) Mitigates SASP-Related Inflammation Induced by Environmental Stressors in Human Epidermal KeratinocytesDOI 10.20944/preprints202003.0192.v1Read

Nicotinamide Prevents UVB- and Oxidative Stress‒Induced Photoaging in Human Primary KeratinocytesSemantic proximity Read

Inflammatory Molecules Associated with Ultraviolet Radiation-Mediated Skin AgingSemantic proximity Read

Cellular Senescence and Inflammaging in the Skin MicroenvironmentSemantic proximity Read

Role of PGE-2 and Other Inflammatory Mediators in Skin Aging and Their Inhibition by Topical Natural Anti-InflammatoriesSemantic proximity Read

NAD in Skin: Therapeutic Approaches for NiacinSemantic proximity Read

Synergistic interplay of UV radiation and urban particulate matter induces impairment of autophagy and alters cellular fate in senescence‐prone human dermal fibroblastsSemantic proximity Read

Metabolic dysfunction in human skin: Restoration of mitochondrial integrity and metabolic output by nicotinamide (niacinamide) in primary dermal fibroblasts from older aged donorsSemantic proximity Read

TLR4-mediated activation of the ERK pathway following UVA irradiation contributes to increased cytokine and MMP expression in senescent human dermal fibroblastsSemantic proximity Read

Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin agingSemantic proximity Read

Ultraviolet Induced Skin InflammationSemantic proximity Read

Modulation of PPARγ Provides New Insights in a Stress Induced Premature Senescence ModelSemantic proximity Read

Effects of Niacin Restriction on Sirtuin and PARP Responses to Photodamage in Human SkinSemantic proximity Read