Article

Model-Free Multiparametric Analysis of SHG Images Reveals Collagen Signatures in Breast Cancer

2026-02-20

Abstract excerpt

<title>Abstract</title> <p> We present a novel multiparametric approach for analyzing high-resolution polarization-resolved Second-Harmonic Generation (pSHG) images to identify aligned collagen bundles in histological samples of human breast cancer. This method introduces a model-free optical biomarker—Polarization Asymmetry (PA)—which quantify collagen supramolecular organization without relying on assumed symm...

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Literature Corpus work: f579fdc9-9612-58af-bc95-46543ead3c93
DOI: 10.21203/rs.3.rs-8427731/v1

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