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Article

Coordinated gripping of substrate by subunits of a AAA+ proteolytic machine.

Nature chemical biology - 1 Mar 2015

Iosefson Ohad, Nager Andrew R, Baker Tania A, Sauer Robert T

Abstract excerpt

Hexameric ATP-dependent proteases and protein remodeling machines use conserved loops that line the axial pore to apply force to substrates during the mechanical processes of protein unfolding and translocation. Whether loops from multiple subunits act independently or coordinately in these processes is a critical aspect of the mechanism but is currently unknown for any AAA+ machine. By studying covalently linked...

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Share to Adenosine Triphosphate
Share to ATP-Dependent Proteases
Share to ATPases Associated with Diverse Cellular Activities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endopeptidase Clp

Share to Molecular Chaperones

Share to Peptide Hydrolases

Share to Protein Unfolding

Share to Translocation, Genetic

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Identifiers

PMID: 25599533
DOI: 10.1038/nchembio.1732
PMCID: PMC4333055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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