Article
Comparative ontogeny, processing, and segmental distribution of the renal chloride channel, ClC-5.
Kidney international - 1 Jan 2004
Jouret François, Igarashi Takashi, Gofflot Françoise, Wilson Patricia D, Karet Fiona E, Thakker Rajesh V, Devuyst Olivier
Abstract excerpt
BACKGROUND: The renal chloride channel ClC-5, which is responsible for Dent's disease, is coexpressed with the vacuolar H+-ATPase in proximal tubules (PT) and alpha-type intercalated cells (IC) of the mature kidney. Neonatal cases of Dent's disease suggest that ClC-5 distribution must be acquired before birth. However, the ontogeny of ClC-5, and its processing and segmental distribution with respect to related...
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