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Plasma neurofilament light chain: A potential prognostic biomarker of dementia in adult Down syndrome patients

5 Apr 2019

Abstract excerpt

People with Down syndrome (DS) are at high risk of developing Alzheimer disease (AD) with aging. The diagnosis and treatment trials are hampered by a lack of reliable blood biomarkers. Plasma neurofilament light chain (NfL) is one of the established biomarkers of AD, suggesting that it may be useful as an indicator of dementia in DS patients. The aims of this study were: 1) to examine whether plasma levels of NfL...

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PMID: 30951523
DOI: 10.1371/journal.pone.0211575

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