Article

Intermediate repeat alleles at polyglutamine repeat loci in the Indian population

2025-11-25

Abstract excerpt

<h4>ABSTRACT</h4> An expansion of trinucleotide repeats beyond a threshold, at particular loci, is linked to several diseases. The prevalence of these expansion-linked disorders varies across populations, and may be influenced by the prevalence of sub-threshold intermediate alleles, which are prone to expand. The effect of somatic instability of these repeats, adds further complexity to the role of intermediate r...

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Literature Corpus work: f456ea9f-f983-5413-a102-270ff92f570f
DOI: 10.1101/2025.11.22.25340801

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