Monocyte-derived macrophage recruitment mediated by TRPV1 is required for eardrum wound healing

Abstract excerpt

The tympanic membrane (TM), or eardrum, is a thin, sensitive tissue critical for hearing by vibrating and transmitting sound waves to the inner ear. TM perforation and development of otitis media and conductive hearing loss are commonly seen in the clinic. In this study, we demonstrate the role of TRPV1 signaling mediated macrophage recruitment and angiogenesis in TM repair. By creating a wounded TM mouse model wi...

Topics

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• Bone and Bones
• Bone Regeneration
• Calcitonin Gene-Related Peptide
• Human Umbilical Vein Endothelial Cells
• Interleukin-6
• Ion Channels and Receptors
• Macrophages
• Neovascularization, Physiologic

Identifiers and source

Literature Corpus work

f45291f9-161a-593c-88b2-f8d2454c89d9

DOI

10.1101/2025.02.03.635565