Article

Nocturnal increase of concentration of circulating tumor DNA in metastatic colorectal cancer patients with disease control but not with progressive disease

2025-12-10

Abstract excerpt

<title>Abstract</title> <p> The utility of liquid biopsy in clinical oncology is often compromised by low concentration of tumor-derived fragments. Recent study demonstrated a nocturnal peak in the amount circulating tumor cells during the deep sleep phase (~ 4 a.m.). This study questioned whether the same peak is characteristic of circulating tumor DNA (ctDNA).Plasma samples were collected from 19 RAS/RAF-mutat...

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Literature Corpus work: f3f54bcc-3b7b-5237-8aa9-e7b1b7b9b99d
DOI: 10.21203/rs.3.rs-7761150/v1

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