Article

Subclonal IDH1/2 Mutations as a Targetable Vulnerability in Vascular Tumors

2026-05-17

Abstract excerpt

Despite extensive sequencing, the genetic etiology of sporadic angiosarcoma remains poorly defined (1-3). Maffucci syndrome, characterized by vascular tumors and elevated cancer risk, is driven by mosaic gain-of-function mutations in IDH1/2 (4,5), though these have not been reported in sporadic angiosarcoma. We identify recurrent, low–variant allele frequency hotspot mutations in IDH1/2 in over half of sporadic a...

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Literature Corpus work: f3caebbe-23dd-5f29-9dfd-66a164fe1e38
DOI: 10.64898/2026.05.14.725132

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