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Comparative genomics of <i>Mycobacterium africanum</i> Lineage 5 and Lineage 6 from Ghana suggests different ecological niches

2017-10-20

Abstract excerpt

Mycobacterium africanum ( Maf ) causes up to half of human tuberculosis in West Africa, but little is known on this pathogen. We compared the genomes of 253 Maf clinical isolates from Ghana, including both L5 and L6. We found that the genomic diversity of L6 was higher than in L5, and the selection pressures differed between both groups. Regulatory proteins appeared to evolve neutrally in L5 but under purifying...

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Literature Corpus work: f37dbb55-7c29-5fbf-9f96-06836a43f1ed
DOI: 10.1101/202234

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