Comparative genomics of Mycobacterium africanum Lineage 5 and Lineage 6 from Ghana suggests distinct ecological niches.

doi:10.1038/s41598-018-29620-2

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Comparative genomics of Mycobacterium africanum Lineage 5 and Lineage 6 from Ghana suggests distinct ecological niches.

Scientific reports - 26 Jul 2018

Otchere Isaac Darko, Coscollá Mireia, Sánchez-Busó Leonor, Asante-Poku Adwoa, Brites Daniela, Loiseau Chloe, Meehan Conor, Osei-Wusu Stephen, Forson Audrey, Laryea Clement, Yahayah Abdallah Iddrisu, Baddoo Akosua, Ansa Gloria Akosua, Aboagye Samuel Yaw, Asare Prince, Borrell Sonia, Gehre Florian, Beckert Patrick, Kohl Thomas A, N'dira Sanoussi, Beisel Christian, Antonio Martin, Niemann Stefan, de Jong Bouke C, Parkhill Julian, Harris Simon R, Gagneux Sebastien, Yeboah-Manu Dorothy

Abstract excerpt

Mycobacterium africanum (Maf) causes a substantial proportion of human tuberculosis in some countries of West Africa, but little is known on this pathogen. We compared the genomes of 253 Maf clinical isolates from Ghana, including N = 175 Lineage 5 (L5) and N = 78 Lineage 6 (L6). We found that the genomic diversity of L6 was higher than in L5 despite the smaller sample size. Regulatory proteins appeared to evolve...

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PMID: 30050166
DOI: 10.1038/s41598-018-29620-2
PMCID: PMC6062541

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