Article

Phenotype-associated spatial biomarker discovery in spatial transcriptomics with spHOT

2026-08-17

Abstract excerpt

Spatial transcriptomics now profiles patient cohorts at single-cell resolution, enabling analysis of disease-associated cell organization in situ. However, discovering such spatial biomarkers remains challenging because relevant structures occur at unknown scales and cell-or niche-level annotations are rarely available. We present spHOT, a deep learning framework that localizes phenotype-associated spatial biomark...

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Literature Corpus work: f2d282b5-4df5-5d52-ba21-d181bb1175dc
DOI: 10.64898/2026.08.11.744312

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