Article

<i>In vitro</i> culture of freshly isolated <i>Trypanosoma brucei brucei</i> bloodstream forms results in gene copy-number changes

2021-06-10

Abstract excerpt

Most researchers who study unicellular eukaryotes work with an extremely limited number of laboratory-adapted isolates that were obtained from the field decades ago, but the effects of passage in laboratory rodents, and adaptation to in vitro culture, have been little studied. For example, the vast majority of studies of Trypanosoma brucei biology have concentrated on just two strains, Lister 427 and EATRO1125,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f2c31bfd-68fb-58ef-b4bf-788da8cc127a
DOI: 10.1101/2021.06.10.446608

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>In vitro</i> culture of freshly isolated <i>Trypanosoma brucei brucei</i> bloodstream forms results in gene copy-number changesDOI 10.1101/2021.06.10.446608Read

In vitro culture of freshly isolated Trypanosoma brucei brucei bloodstream forms results in gene copy-number changesSemantic proximity Read

Developmental changes and metabolic reprogramming during establishment of infection and progression of <i>Trypanosoma brucei brucei</i> through its insect hostSemantic proximity Read

Clinical <i>Trypanosoma cruzi</i> isolates share a common antigen repertoire that is absent from culture adapted strainsSemantic proximity Read

RNA-Seq analysis validates the use of culture-derived Trypanosoma brucei and provides new markers for mammalian and insect life-cycle stagesSemantic proximity Read

Mechanisms of life cycle simplification in African trypanosomes.Semantic proximity Read

<i>Trypanosoma brucei</i> cattle infections contain cryptic transmission-adapted bloodstream forms at low parasitaemiaSemantic proximity Read

<i>Trypanosoma cruzi</i> isolates naturally adapted to congenital transmission display a unique strategy of transplacental passageSemantic proximity Read

Comparative genomics and transcriptomics of the Spiroplasma glossinidia strain sGff reveal insights into host interaction and trypanosome resistance in Glossina fuscipes fuscipesSemantic proximity Read

Gene and Chromosomal Copy Number Variations as an Adaptive Mechanism Towards a Parasitic Lifestyle in TrypanosomatidsSemantic proximity Read

Monomorphic <i>Trypanozoon</i> : towards reconciling phylogeny and pathologiesSemantic proximity Read

The louse-borne human pathogen <i>Bartonella quintana</i> is a genomic derivative of the zoonotic agent <i>Bartonella henselae</i>Semantic proximity Read

Mechanisms of life cycle simplification in African trypanosomesSemantic proximity Read