Article

<i>Fusobacterium nucleatum</i> produces previously unappreciated AHR-activating metabolites and promotes CRC cell proliferation via the AHR-TERT axis

2025-09-25

Abstract excerpt

<h4>SUMMARY</h4> Fusobacterium nucleatum ( Fn ) is prevalently enriched in colorectal cancer (CRC), promoting CRC progression. However, Fn -derived small molecules and their host target pathways in CRC remain largely underexplored. Here, we identify that Fn produces previously unrecognized three indole-containing metabolites, fusotrisindoline (FTIN), streptindole (STIN), and trisindoline (TIN). Using AHR repor...

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Identifiers and source

Literature Corpus work: f27787c9-4329-5223-888e-8a76034fd518
DOI: 10.1101/2025.09.25.678601

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