Article

Identification of general acid catalyst for the ATPase activity of Lynch syndrome-related MutL homologs

2021-07-10

Abstract excerpt

Mutations of mismatch repair MutL homologs are causative of a hereditary cancer, Lynch syndrome. Investigation of MutL facilitates genetic diagnoses essential for cancer risk managements and therapies. We characterized MutL homologs from human and a hyperthermophile, Aquifex aeolicus , (aqMutL) to reveal the catalytic mechanism for the ATPase activity. Although existence of a general acid catalyst had not been co...

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Literature Corpus work: f257e963-01dd-5bd0-bc50-d4417b61592c
DOI: 10.1101/2021.07.09.451751

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