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Serial Cell-Culture Passage of Severe Fever with Thrombocytopenia Syndrome Virus Attenuates Virulence and Confers Protective Immunity in Mice.

Viruses - 8 Mar 2026

Kim Jihee, Kim Young-Eui, Kang Hae Ji, Ryou Jungsang, Chu Hyuk, Yun Seok-Min

Abstract excerpt

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne viral disease with high case-fatality rates in East Asia, yet no licensed vaccines are currently available. Here, we generated attenuated severe fever with thrombocytopenia syndrome virus (SFTSV) strains through serial passage in Huh-7 cells and evaluated their pathogenicity, immunogenicity, and protective efficacy. Attenuation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41902241
DOI: 10.3390/v18030333
PMCID: PMC13030574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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