Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotype-Dependent Virulence of Severe Fever with Thrombocytopenia Syndrome Virus in a Mouse Challenge Model.

International journal of molecular sciences - 30 Mar 2026

Choi Eun Bee, Kim Seungyeon, Moon Seo Young, Jang Eun Young, Lee Yookyoung, Ouh In-Ohk

Abstract excerpt

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease with high case-fatality rates in East Asia. The causative agent, SFTS virus (SFTSV; also known as Dabie bandavirus), exhibits genotype-dependent differences in pathogenicity. However, infection models that recapitulate these variations and can be applied for vaccine and therapeutic evaluation are still lacking. In this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Models, Animal
Share to Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Mice, Knockout

Share to Receptor, Interferon alpha-beta

Share to Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 41977334
DOI: 10.3390/ijms27073148
PMCID: PMC13073972

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotype-Dependent Virulence of Severe Fever with Thrombocytopenia Syndrome Virus in a Mouse Challenge Model.PMID 41977334Read ↗

Serial Cell-Culture Passage of Severe Fever with Thrombocytopenia Syndrome Virus Attenuates Virulence and Confers Protective Immunity in Mice.Semantic proximity Read ↗

Age-dependent pathogenicity of two severe fever with thrombocytopenia syndrome viruses in a ferret modelSemantic proximity Read ↗

Genetic and pathogenic diversity of severe fever with thrombocytopenia syndrome virus (SFTSV) in South Korea.Semantic proximity Read ↗

Effect of genomic variations in severe fever with thrombocytopenia syndrome virus on the disease lethalitySemantic proximity Read ↗

A natural variation in the RNA polymerase of severe fever with thrombocytopenia syndrome virus enhances viral replication and in vivo virulenceSemantic proximity Read ↗

The Pathogenesis of Severe Fever with Thrombocytopenia Syndrome Virus Infection in Alpha/Beta Interferon Knockout Mice: Insights into the Pathologic Mechanisms of a New Viral Hemorrhagic FeverSemantic proximity Read ↗

Advances in research on severe fever with thrombocytopenia syndrome virusSemantic proximity Read ↗

Modeling Severe Fever with Thrombocytopenia Syndrome Virus Infection in Golden Syrian Hamsters: Importance of STAT2 in Preventing Disease and Effective Treatment with Favipiravir.Semantic proximity Read ↗

Cross-genotype protection of live-attenuated vaccine candidate for severe fever with thrombocytopenia syndrome virus in a ferret modelSemantic proximity Read ↗

Effect of Severe Fever With Thrombocytopenia Syndrome Virus Genotype on Disease Severity, Viral Load, and Cytokines in South KoreaSemantic proximity Read ↗

Genetic diversity and evolutionary history of Korean isolates of severe fever with thrombocytopenia syndrome virus from 2013-2016.Semantic proximity Read ↗

The Endless Wars: Severe Fever With Thrombocytopenia Syndrome Virus, Host Immune and Genetic FactorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.