Article

Single-cell mapping of maternal–fetal cross-talk in preeclampsia

2025-12-08

Abstract excerpt

<title>Abstract</title> <p>Preeclampsia (PE) arises from placental dysfunction, yet the cellular events that distinguish early-onset PE (EOPE) from late-onset PE (LOPE) are poorly defined. We generated a comprehensive single-cell atlas of the placenta of women with and without PE (78 patients), integrating maternal–fetal genotyping, multi-dimensional clustering, and cell–cell communication analysis. PE reshaped t...

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Literature Corpus work: 130f399f-5eac-584a-98c7-ec6fb28a6737
DOI: 10.21203/rs.3.rs-8254581/v1

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