Article
Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension
2019-06-27
Abstract excerpt
Experimental ocular hypertension induces senescence of retinal ganglion cells (RGCs) that mimicks events occurring in human glaucoma. Senescence-related chromatin remodeling leads to profound transcriptional changes including the upregulation of a subset of genes that encode multiple proteins collectively referred to as the senescence-associated secretory phenotype (SASP). Emerging evidence suggests that the prese...
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Identifiers and source
- Literature Corpus work
- f23b894b-2e52-5524-b520-65fef541e910
- DOI
- 10.1101/684811