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Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension

22 Dec 2019

Abstract excerpt

Experimental ocular hypertension induces senescence of retinal ganglion cells (RGCs) that mimics events occurring in human glaucoma. Senescence-related chromatin remodeling leads to profound transcriptional changes including the upregulation of a subset of genes that encode multiple proteins collectively referred to as the senescence-associated secretory phenotype (SASP). Emerging evidence suggests that the...

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PMID: 31867890
DOI: 10.1111/acel.13089

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