Article

p.E152K-STIM1 mutation deregulates Ca <sup>2+</sup> signaling contributing to chronic pancreatitis

2020-01-23

Abstract excerpt

<h4>ABSTRACT</h4> Since deregulation of intracellular Ca 2+ can lead to intracellular trypsin activation and STIM1 (stromal interaction molecule-1) protein is the main regulator of Ca 2+ homeostasis in pancreatic acinar cells, we explored the Ca 2+ signaling in 37 STIM1 variants found in three pancreatitis patient cohorts. Extensive functional analysis of one particular variant, p.E152K, identified in three pa...

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Literature Corpus work: f236810f-b279-5542-b7f8-a9db628fdb87
DOI: 10.1101/2020.01.22.916254

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