Article

A fly model of SCA36 reveals combinatorial neurotoxicity of hexanucleotide and dipeptide repeats

2025-05-16

Abstract excerpt

Spinocerebellar ataxia type 36 (SCA36) is a neurodegenerative disease caused by expanded (GGCCTG)n hexanucleotide repeat sequence in the NOP56 gene. While the expanded repeats could transcribe and form toxic RNA foci within neurons, recent evidence indicates that translation of these repeats produces dipeptide repeats (DPR) that contribute to neurotoxicity. The relative impact of hexanucleotide RNA repats (HRR) an...

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Literature Corpus work: f1cd8ba2-f17d-557b-a24a-ce1558c7c942
DOI: 10.1101/2025.05.15.25327061

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